Custom method development

Tailored analytical solutions

We specialize in developing bespoke LC-MS workflows for metabolites that fall outside our standard panels. From low-abundance signaling lipids to material-specific adsorption studies, our team works closely with you to design and implement precise methods tailored to your unique research objectives.

Specialized analytical expertise

Our custom method development focuses on unique metabolites beyond our standard panels. From low-abundance signaling lipids to specialized material studies, we design precise LC-MS workflows tailored to your specific research objectives.

Key features of our service

  • Method Optimization: Custom development of extraction and separation protocols to ensure maximum sensitivity for challenging analytes.

  • Accuracy: Every custom workflow undergoes rigorous testing to ensure reproducible and reliable quantification across your specific matrices.

  • Diverse Application Support: Proven expertise in areas ranging from organ-on-chip bioavailability to rodent-specific metabolic adaptations.

Examples

Phosphatidylinositol Phosphates (PIPs)

Developed a sensitive LC-MS workflow for accurate detection and quantification of low-abundance PIP species, enabling detailed investigation of lipid signaling pathways and membrane dynamics.

Ketone bodies panel – Acetoacetic Acid & 3-Hydroxybutyric Acid

Built a robust LC-MS method for precise quantification of key ketone bodies in biological samples, supporting metabolic studies in diabetes, exercise physiology, and mitochondrial research.

Expanded bile acid panel for rat plasma

Adapted our existing human bile acid method (BACID) by incorporating rat-specific bile acids, enabling accurate translational and preclinical metabolomics studies in rodent models.

Sorption & release analysis for Organs-on-Chip

Developed an LC-MS method to quantify adsorption and release of small molecules in PDMS and COC materials, helping organ-on-chip researchers evaluate compound loss, bioavailability, and experimental reliability.

MIX&MATCH

Our Mix & Match service offers a flexible approach to meet your specific experimental needs:

Our Custom Method Development service also includes a MIX & MATCH approach, allowing you to combine existing analytical panels, select only specific metabolites from a larger method, or adapt existing workflows to fit your experimental design.

Whether you need just a few targeted compounds or a hybrid panel tailored to your hypothesis, we modify and optimize methods to match your biological question, ensuring flexibility without compromising analytical quality.

Targeted Flexibility

Create custom-tailored solutions without compromising analytical quality.

Adaptive Workflows

Modify and optimize protocols to match your unique biological questions.

Hybrid
Panels

Combine existing panels or select specific metabolites from larger methods.